Sign In

In-solution antibody purification


  • Currently industrial antibodies are harvested from cell suspension growth media by column chromatography – an expensive multi-step process.
  • Aqueous two-phase systems (ATPS) are an interesting and scalable alternative to column chromatography for protein purification. VTT has created a novel antibody harvest reagent by fusing antibody binding domains of Protein A with fungal hydrophobins. This reagent can be used to selectively harvest antibodies with ATPS method directly from cell culture supernatant.
  • This technology solves bottlenecks in existing antibody purification procedures and supports development of continuous or single-use process thus enabling affordable antibodies for growing world wide market in diagnostics, research and medicine. In-solution antibody purification



TRL 4. Technology validated in laboratory environment.