A revolutionary discovery regarding motile cancer cells made by research
scientists at VTT Technical Research Centre of Finland and the University of
Turku is challenging previous conceptions. The results have been published on
25 July 2011 in the Journal of Cell Biology, one of the most renowned journals
in the field.
It has long been held that cells use different mechanisms for regulating
migration and growth. This conception was proven false by research scientists
Anja Mai and Stefan Veltel from the research team of Professor Johanna Ivaska.
Their findings on aggressively spreading breast cancer cells revealed –
completely contrary to previous expectations – that a single cell protein
(p120RasGAP) acts as an important inhibitor of both cell migration and growth.
cells are characterised by traits such as uncontrollable growth and the
ability to metastasise. The findings of the research team now show that the
regulation of these two deadly traits in cells is interconnected, which may be
an important piece of information in the future development of medicines.
Ivaska has been interviewed in the journal’s podcast
(http://www.jcb.org/biobytes), which highlights a handful of leading
international studies each month. The interview can be heard in the podcast
archive of the journal: http://www.jcb.org/biobytes.